Alzheimer's disease 1) Primary Source - "FAD Mutations in Presenilin-1 or Amyloid Precursor Protein Decrease the Efficacy of a y-Secretase Inhibitor: Evidence for Direct Involvement of PS1 in the y-Secretase Cleavage Complex" Alzheimer's disease (AD) causes mutations in presenilin-1 (PS1) and presenilin -2 (PS2) that increase the formation of amyloid B-peptides (AB). AB is formed by increasing the cleavage of B-amyloid precursor protein (APP), and the cleavage of APP is performed by y-secretase. So in simpler …showed first 75 words of 789 total…

…showed last 75 words of 789 total…studies have been performed to show the effect of Ibuprofen. Mice were modified to carry gene that causes AD, they developed plaques, and upon receiving ibuprofen there was a decrease in brain inflammation. When compared to the untreated mice, the treated mice had half the number of plaques and half the total amount of brain amyloid. A similar study on deceased elderly people showed that those who used NSAIDs showed less amyloid on the brain